| Winston-Salem to Stony Brook (New York) | 508.49 mi (818.34 km) |
| Winston-Salem to Storm Lake (Iowa) | 914.87 mi (1,472.33 km) |
| Winston-Salem to Storrs (Connecticut) | 583.12 mi (938.44 km) |
| Winston-Salem to Stoughton (Wisconsin) | 670.28 mi (1,078.70 km) |
| Winston-Salem to Stow (Ohio) | 356.21 mi (573.27 km) |
| Winston-Salem to Streamwood (Illinois) | 589.07 mi (948.01 km) |
| Winston-Salem to Streator (Illinois) | 577.78 mi (929.84 km) |
| Winston-Salem to Streetsboro (Ohio) | 359.69 mi (578.87 km) |
| Winston-Salem to Strongsville (Ohio) | 369.77 mi (595.09 km) |
| Winston-Salem to Stuart (Florida) | 615.41 mi (990.41 km) |
| Winston-Salem to Stuarts Draft (Virginia) | 148.62 mi (239.18 km) |
| Winston-Salem to Sturgis (Michigan) | 481.13 mi (774.30 km) |
| Winston-Salem to Suamico (Wisconsin) | 717.89 mi (1,155.33 km) |
| Winston-Salem to Sudley (Virginia) | 239.59 mi (385.58 km) |
| Winston-Salem to Suffern (New York) | 478.29 mi (769.74 km) |
