| Zafferana Etnea to Spello | 388.19 mi (624.74 km) |
| Zafferana Etnea to Spilamberto | 518.66 mi (834.70 km) |
| Zafferana Etnea to Spilimbergo | 594.42 mi (956.63 km) |
| Zafferana Etnea to Spinea | 560.47 mi (901.99 km) |
| Zafferana Etnea to Spoleto | 372.91 mi (600.14 km) |
| Zafferana Etnea to Spoltore | 333.57 mi (536.83 km) |
| Zafferana Etnea to Spresiano | 578.52 mi (931.04 km) |
| Zafferana Etnea to Squinzano | 247.26 mi (397.92 km) |
| Zafferana Etnea to Statte | 228.80 mi (368.23 km) |
| Zafferana Etnea to Stezzano | 617.77 mi (994.21 km) |
| Zafferana Etnea to Strada | 453.23 mi (729.40 km) |
| Zafferana Etnea to Stradella | 592.77 mi (953.97 km) |
| Zafferana Etnea to Striano | 218.37 mi (351.43 km) |
| Zafferana Etnea to Subiaco | 312.22 mi (502.47 km) |
| Zafferana Etnea to Sulmona | 307.92 mi (495.55 km) |
